Arginine magic: Arginine kills tumor cells when presented in saline

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Selectively Kills Tumor Cells

nloaded 1 kinase activates multiple transcription factors and regulates the level of reactive oxygen species We have previously reported that ablation of TAK1 in keratinocytes causes hypersensitivity to ROSd cell apoptosis. It is known that some tumor cells produce ROS at higher levels compared with normal e used inducible epidermal-specific TAK1 knockout mice and examined whether ablation of T...

متن کامل

Anti-tumor activity of arginine deiminase via arginine deprivation in retinoblastoma.

In spite of recent advances in the treatment of retinoblastoma, chemotherapy is still challenging in high-stage intraocular retinoblastoma or metastatic retinoblastoma. Here, we investigated whether arginine deprivation via arginine deiminase (ADI) could be a new anti-tumor therapy in retinoblastoma cells. Expression of argininosuccinate synthetase (ASS) was detected in human retinoblastoma tis...

متن کامل

Metabolic Reprogramming in Arginine Deiminase-Resistant Cells

Authors’ Affiliations: Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida; Department of Neurology and Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland *These authors contributed equally Corresponding Author: Macus T...

متن کامل

Arginine-mediated RNA recognition: the arginine fork.

Short peptides that contain the basic region of the HIV-1 Tat protein bind specifically to a bulged region in TAR RNA. A peptide that contained nine arginines (R9) also bound specifically to TAR, and a mutant Tat protein that contained R9 was fully active for transactivation. In contrast, a peptide that contained nine lysines (K9) bound TAR poorly and the corresponding protein gave only margina...

متن کامل

Arginine-glycine-aspartic acid (RGD)-peptide binds to both tumor and tumor-endothelial cells in vivo.

Targeting tumor cells or tumor vasculature by peptides is a promising strategy for delivering cytotoxic drugs for cancer therapy. The identification of efficient targeting peptides depends on the availability of informative methods for determining cellular binding specificities. Here, we have used fluorescence-activated cell-sorting (FACS) analysis in combination with an isopentane freezing met...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: The FASEB Journal

سال: 2008

ISSN: 0892-6638,1530-6860

DOI: 10.1096/fasebj.22.1_supplement.1198.5